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In this issue of Ortho Restore, specialists discuss emerging paradigms for end-stage ankle arthritis, cellular senescence, and translating cells from bench to bedside.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Review the feasibility of total ankle arthroplasty procedures.
  • Discuss the role of cellular senescent in age-associated intervertebral disc degeneration.
  • Review the efficacy of therapeutic interventions for intervertebral disc degeneration.


Dr. Vo reports current funding from the NIH/NIA through an R01 AG044376-01 grant.

Dr. Huard serves as a consultant for Steadman Philippon Research Institute.

Dr. Hogan reports promotional speaking engagements with ECG Consultants – Healthcare, Management Consultant Group 

Drs. Yan, Chambers and Fu report no relationships with proprietary entities producing health care goods and services.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

This course has been expired.