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Drs. Jonathan K. Alder and John F. McDyer present on lung transplantation for idiopathic pulmonary fibrosis and discuss the importance of telomere length and genome sequencing. Dr. Paul Szabolcs also reviews a clinical study on tandem lung and bone marrow transplantation and discusses the results. 

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Identify telomere-mediated disease and recognize their clinical presentation
  • Explain the importance of genetics and potential use of whole genome sequencing in identifying patients with telomere-mediated disease
  • Describe the mechanistic consequences of telomere-mediated disease and their likely co-morbidities
  • Recognize primary immune deficiency diseases (CVID, CGD) that may lead to pulmonary failure
  • Analyze sequential LTX and BMT from the same donor and implement planned withdrawal of immunosuppression and increase tolerance
  • Identify cadaveric vertebral bone marrow that contains functional hematological stem cells suitable for BMT

Disclosures:

Dr. Paul Szabolcs has reported no relevant relationships with entities producing health care goods or services.

Dr. John F. McDyer has financial interests with the following entity or entities producing health care goods or services as indicated below:

  •  Grant/Research Support: NIH, CF Foundation

Jonathan K. Alder, PhD has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: Funding from the NIH

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (1.25) continuing education units (CEU) which are equivalent to 1.25 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at http://ccehs.upmc.com and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

ABIM MOC Part 2 Credit:

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

To receive your ABIM MOC Part 2 credit, you will need to complete the post-test with a pass rate of 100% and provide your date of birth and ABIM number, along with the other required fields. This information will be shared with the American Board of Internal Medicine using the Accreditation Council for Continuing Medical Education Program and Activity Reporting System.

Release Date: 5/2/2019 | Last Modified On: 5/2/2019 | Expires: 5/4/2020

 

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