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Drs. Benjamin L. Shneider, George V. Mazariegos, and Ira J. Fox give presentations at the 2012 conference, Challenging the Paradigms: Liver Transplantation for Metabolic Disease.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Discuss rationale for liver transplantation
  • Describe CNI-Decision Analysis
  • Discuss patient-specific predictions for morbidity and mortality
  • Discuss the  current state of pediatric liver transplant
  • Compare decision making in timing for transplant between chronic liver disease and metabolic disease
  • Review determinants of  outcomes
  • Compare liver transplantation and hepatocyte transplantation (HT)
  • Describe use of HT as a minimally invasive potential therapy for some patients with liver-based metabolic diseases
  • Discuss management challenges of immune suppression when rejection cannot be easily diagnosed

Reading Resources:

  1. Strauss et. al. Eur. J. Pediatr. 2006;165:306.
  2. Hepatology 1996;24:311-315.
  4. Goh A; Terasaki Foundation Laboratory, Los Angeles, CA, USA. An analysis of liver transplant survival rates from the UNOS registry. Clin Transpl. 2008:19-34.
  5. Porter ME. What is Value in Health Care? NEJM 2012: 363:26.
  6. Ng VL, Alonso EM, Bucuvalas JC, Cohen G, Limbers CA, Varni JW, Mazariegos G, Magee J, McDiarmid SV, Anand R; Studies of Pediatric Liver Transplantation (SPLIT) Research Group. Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience. J Pediatr. 2012 May;160(5):820-6.
  7. Bellin MD, et al. Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes. Am J Transplant 2012.
  8. Ribes-Koninckx C, Ibars EP, Calzado Agrasot MÁ, Bonora-Centelles A, Miquel BP, Vila Carbó JJ, Aliaga ED, Pallardó JM, Gómez-Lechón MJ, Castell JV Clinical outcome of hepatocyte transplantation in four pediatric patients with inherited metabolic diseases. Cell Transplant. 2012;21(10):2267-82.
  9. Deng XG, Qiu RL, Li ZX, Zhang J, Zhou JJ, Wu YH, Zeng LX, Tang J. Selection of Hepatocyte-Like Cells from Mouse Differentiated Embryonic Stem Cells and Application in Therapeutic Liver Repopulation. Cell Physiol Biochem. 2012;30(5):1271-1286.


Drs. Shneider, Mazariegos, and Fox  have no relevant relationships with any entities producing health care goods or services.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1.0 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/19/2013 | Last Modified On: 3/19/2013 | Expires: 3/19/2014

This course has been expired.