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In this Synergies publication, UPMC Drs. K.N. Roy Chengappa, Jessica Gannon, and Deepak K. Sarpal  provide an overview of clozapine’s role in the current treatment of psychotic disorders. They focus on historical context prior to FDA approval, followed by a review of key evidence supporting its use. The Doctors also discuss future directions for clozapine’s place within our treatment algorithms and novel research efforts to develop precision medicine approaches to optimize its use. 

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Recall key trials that demonstrate clozapine's utility
  • Explain rates of clozapine utilization around the world
  • Describe evidence for clozapine's place within schizophrenia treatment algorithms over the past 30 years


No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.


Accreditation Statement:

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 0.5 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.


Release Date: 2/25/2019 | Last Modified On: 3/11/2022 | Expires: 2/21/2023

This course has been expired.