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In this Synergies publication, UPMC Drs. K.N. Roy Chengappa, Jessica Gannon, and Deepak K. Sarpal  provide an overview of clozapine’s role in the current treatment of psychotic disorders. They focus on historical context prior to FDA approval, followed by a review of key evidence supporting its use. The Doctors also discuss future directions for clozapine’s place within our treatment algorithms and novel research efforts to develop precision medicine approaches to optimize its use. 

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Recall key trials that demonstrate clozapine's utility
  • Explain rates of clozapine utilization around the world
  • Describe evidence for clozapine's place within schizophrenia treatment algorithms over the past 30 years


Drs. K.N. Roy Chengappa, Jessica Gannon, and Deepak K. Sarpal have reported no relevant relationships with entities producing health care goods or services.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .50 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (.05) continuing education units (CEU) which are equivalent to .50 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 2/25/2019 | Last Modified On: 3/5/2020 | Expires: 2/25/2021

This course has been expired.