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Robyn Domsic MD, MPH, reviews the treatment options for the cutaneous and pulmonary manifestations of systemic sclerosis.

Educational Objectives 

Upon completion of this activity, participants should be able to:

  • Recognize the clinical phenotypes / manifestations of systemic sclerosis for which immunosuppressive or anti-fibrotic therapy should be considered
  • Explain the literature to support the common use of medications to treat early diffuse SSc. Recognize agents currently undergoing investigational trial for this indication
  • Identify which medications are currently FDA approved or have orphan drug designation for the management of SSc-ILD
  • Explain the literature to support the use of cyclophosphamide, mycophenolate, nintedanib and tocilizumab for the treatment of SSc-related ILD 
  • Explain the stem cell transplant literature in SSc, and appreciate the often narrow window of therapeutic use


All individuals in a position to control the content of this education activity have disclosed all financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All of the relevant financial relationships for the individuals listed below have been mitigated

  • Consultant: CSL Behring, Inc

Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh designates enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

For your credit transcript, please access our website four weeks postcompletion at and follow the link to the Credit Transcript page.

Release Date: 4/27/2021 | Last Modified On: 7/13/2022 | Expires: 7/8/2023

This course has been expired.