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According to most recent estimates from the U.S. Centers for Disease Control and Prevention (CDC), more than one third of the U.S. adult population has prediabetes. Early interventions that minimize the risk of progression to overt diabetes could therefore have a major impact on individual and population health. Emerging evidence supports an increasingly important role for circadian rhythms in human health and disease. Indeed, the 2017 Nobel Prize in Physiology and Medicine was awarded to Drs. Jeffry Hall, Michael Rosbash, and Michael Young “for their discoveries of molecular mechanisms controlling the circadian rhythm.” However, the role of cir ca dian rhythms in diabetes pathogenesis remains poorly understood. Vijay Yechoor, MD, director of the Diabetes and Beta Cell (?-cell) Biology Center at the University of Pittsburgh, is deciphering the mechanisms linking the molecular clock to diabetes progression with the goal of identifying novel pathways to prevent and treat diabetes.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Recognize the prevalence of Prediabetes in United States, and how to approach a patient with hypertension and hypokalemia in a step-wise manner
  • Interpret social jetlag and the PAC, PRA and the PAC/PRA ratio to narrow down the possible cause of secondary endocrine hypertension
  • Identify imaging modalities for suspected renovascular hypertension, and the glucose threshold for treatment of hypoglycemia
  • Prescribe and adjust insulin regimens to achieve desired glycemic targets and minimize risk for hypoglycemia
  • Discuss the circumstances where use of correction insulin alone (i.e. sliding scale insulin) can be used as monotherapy in a hospitalized patient


Drs. Karslioglu French, O’Doherty, Swami, Stefanovic-Racic, and Yechoor has reported no relevant relationships with entities producing health care goods or services

Dr. Korytkowski has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Consultant: Novo Nordisk

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 3/20/2017 | Last Modified On: 4/10/2019 | Expires: 2/24/2020

This course has been expired.