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Dr. Siamak Moghadam-Kia, Dr. Ximena Ruiz, and Dr. Larry Moreland discuss updates in therapeutic approaches in small-and mixed-vessel vasculitis in this issue of UPMC Rheumatology Grand Rounds.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Review the evolving classifications for vasculitis
  • Discuss current treatments for small- and mixed-vessel vasculitis
  • Describe developing therapies for small- and mixed-vessel vasculitis

Reading Resources:

  1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med. 1997;337:1512-23.
  2. Jauhola O, Ronkainen J, Koskimies O, et al. Clinical course of extrarenal symptoms in Henoch-Schonlein purpura: a 6-month prospective study. Arch Dis Child 2010; 95:871.
  3. Saigal K, Valencia IC, Cohen J, Kerdel FA. Hypocomplementemic urticarial vasculitis with angioedema, a rare presentation of systemic lupus erythematosus: rapid response to rituximab. J Am Acad Dermatol. 2003;49(5 Suppl):S283-5.


Doctors Siamak Moghadam-Kia and Ximena D. Ruiz have reported no relevant relationships with any entities producing health care goods or services.

Dr. Larry W. Moreland receives financial support from Pfizer as chair of a data safety monitoring board. He also receives research grants from Genentech, Human Genome Sciences, Mesoblast, Pfizer, Questcor, Roche, and Sanofi-Aventis.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 11/12/2013 | Last Modified On: 11/12/2013 | Expires: 11/12/2014

This course has been expired.