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Dr. David Brent and colleagues review the definition, significance, assessment, and management of treatment-resistant depression in youth in UPMC Synergies.


To open the document in the page viewer, click the "Read More" button above (note: due to recent changes to the Firefox browser, IE, Chrome or Safari is necessary to access the page viewer). Once you’ve finished reading the document, to receive CME Credit, please complete the following steps:

  1. Close the document window and return to the course page.
  2. Click the orange “Take the CME Evaluation” button.
  3. Complete the registration, evaluation and the post-test pages.

An electronic certificate will be issued and your participation recorded in our database. Please print the certificate and keep it for your records.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Discuss adequate clinical response and adequate dose and duration related to managing treatment-resistant depression.
  • Determine primary diagnosis and rule out covert medication illness
  • Conduct thorough evaluation and develop a multi-strategy management and treatment plan.

Reading Resources:

  1. Brent DA, Kolko D, Birmaher B et al. Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression. J Am Acad Child Adolesc Psychiatry. 1998;37:906-914.
  2. Feeny NC, Silva SG , Reinecke MA et al. An exploratory analysis of the impact of family functioning on treatment for depression in adolescents. J Clin Child Adolesc Psychol. 2009;38:814-825.
  3. Lewis CC, Simons AD, Nguyen LJ et al. Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS ). J Am Acad Child Adolesc Psychiatry. 2010;49:132-140.


Dr. Brent receives research support from NIMH grants. He receives royalties from Guilford Press, royalties from the C-SSRS and royalties from the electronic self-rated version of the C-SSRS from ERT, Inc.. He receives honoraria for presenting at CME events.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditsTM. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to 0.5 contact hours.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 11/1/2011 | Last Modified On: 4/1/2013 | Expires: 4/1/2014

This course has been expired.