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In this review the definition, predictors, approach, and management of treatment-resistant depression in adolescents are described. We conclude with descriptions of some novel interventions that may be treatments of the future for treatment-resistant depression.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Improve diagnostic skills in recognizing treatment resistant depression and adolescents
  • Improve ability to identify factors that contribute to treatment resistant depression in adolescents
  • Improve ability to manage treatment resistant depression in adolescents


Dr. Brent has financial interests with the following entity or entities producing health care goods or services as indicated below:

  • Grant/Research Support: NIMH and AFSP, Once Upon a Time Foundation 
  • Consultant for Healthwise, McKesson
  • Receives royalties from Guildford Press, eRT for the electronic version of the C-SSRS, UpToDate, and sits on the scientific boards of Klingenstein Third Generation Foundation, the American Foundation for Suicide Prevention, and the National Advisory Council of NIMH.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of .5 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.05) continuing education units (CEU) which are equivalent to .5 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 12/10/2018 | Last Modified On: 2/8/2019 | Expires: 12/10/2019

This course has been expired.