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The Division of Pediatric Hematology/Oncology at UPMC Children’s Hospital of Pittsburgh has well over 100 open clinical trials in progress covering numerous aspects of the oncologic spectrum.
Many of these trials are novel, investigator-initiated studies adding to the breadth of the numerous multicenter trials in progress at UPMC Children’s as a part of the Children’s Oncology Group.
In this clinical trials update, we focus on several new studies led by Alberto Broniscer, MD, director of neuro-oncology. Also profiled are investigations being conducted by Kelly Bailey, MD,PhD, a sarcoma specialist in the Division who is investigating the Ewing sarcoma tumor microenvironment.
Neuro-Oncology Trials – Chipping Away At Intractable Illnesses
Dr. Broniscer, director of the nationally recognized neuro-oncology program at UPMC Children’s Hospital of Pittsburgh, leads a robust multidisciplinary clinical apparatus and research program engaged in a diverse array of clinical, translational, and basic science investigations. Dr. Broniscer has more than two decades of clinical and research experience studying brain and spinal cord tumors in children with an emphasis on diffuse intrinsic pontine glioma (DIPG).
A selection of in-progress trials includes the following institutional experimental vaccine studies for low-grade gliomas and ependymomas. For these studies, Dr. Broniscer is collaborating with Ian Pollack MD, chief of pediatric neurosurgery at UPMC Children’s Hospital of Pittsburgh.