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Robert L. Ferris, MD, PhD, director of the UPMC Hillman Cancer Center, presented the results of his clinical trial at the Immuno-Oncology Trials session during the 2018 American Association for Cancer Research (AACR) Annual Meeting in Chicago.
The CheckMate -141 is a Phase 3 open-label, randomized trial evaluating Opdivo (nivolumab) compared with investigator’s choice chemotherapy (cetuximab, docetaxel, or methotrexate) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) after failure on platinum-based therapy.
"The introduction of Immuno-Oncology has the potential to change the treatment landscape of squamous cell carcinoma of the head and neck, compared with the standard of care," said Dr. Ferris. "The sustained overall survival benefit demonstrated by nivolumab in this study is encouraging in SCCHN, which historically has a median survival of less than six months."