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Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases

August 12, 2020

Our organization is conducting a study for patients with primary immunodeficiency and end-stage lung disease. Patients with immunodeficiencies often develop lung complications or infections that make them ineligible for life-saving immunotherapy.

In this study, we are performing a lung transplant as well as a bone marrow transplant from the same donor.

The bone marrow transplant will provide stem cells that should generate a new immune system in the patient, which we expect will resolve the patient’s immunodeficiency and prevent organ rejection.

Initiated by the UPMC Immune Transplant and Therapy Center.

Trial Eligibility

This trial is open to pediatric and adult patients between the ages 10 and 45. For additional requirements and criteria please visit the NIH Clinical Trials website.

Study Start Date: June 20, 2013
Estimated Primary Completion Date: November 2023
Estimated Study Completion Date: November 2024

Learn more about this trial on its NIH Clinical Trials webpage or contact Shawna McIntyre, BSN, RN, at or 412-692-5552.

Lab Team

Principal Investigators:
Paul Szabolcs, MD
John McDyer, MD

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