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The UPMC Newborn Medicine Program has dedicated plans for consensus management of many neonatal conditions, including gastroschisis, congenital diaphragmatic hernia, Pierre Robin sequence, myelomeningocele, NAS, and others. The program is an Extracorporeal Life Support Organization (ELSO) Center of Excellence and a Quality Improvement Leader in the Children’s Hospitals Neonatal Consortium. The program currently includes investigations into developing a new agent to prevent blood clot development in neonates with congenial heart disease and the mechanisms of bilirubin-induced neurotoxicity, among many others.