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Drs. Derek Angus and Bill Chen present on the basic mechanisms and novel therapeutics in Sepsis.

Educational objectives:

Upon completion of this activity, participants should be able to:

  • Improve participant’s understanding in basic mechanism of sepsis.
  • Update participants on potential future sepsis therapies.

Reading Resources:

  1. Chen BB, Coon TA, Glasser JR, McVerry BJ, Zhao J, Zhao Y, Zou C, Ellis BM, Sciurba FC, Zhang Y, *Mallampalli RK. A combinatorial F box protein directed pathway controls TRAF stability to regulate inflammation.  Nat Immunol. 2013 Mar 31. doi: 10.1038/ni.2565. [Epub ahead of print]. PMCID: PMC3631463. Highlighted in Nat Rev Immunol and Nat Rev Drug Design. 
  2. McKelvey AC, Lear T, Dunn SR, Evankovich J, Landino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, Chen BB. RING Finger E3 Ligase PPP1R11 Regulates TLR2 Signaling and Innate Immunity. eLife 2016 Nov 2;5. pii: e18496. doi: 10.7554/eLife.18496. PMID: 27805901, PMCID: PMC5092053.
  3. Hotchkiss RS and Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nature Reviews Immunology 6, 813-822. 2006 Nov doi:10.1038/nri1943


Drs. Angus and Chen has reported no relevant relationships with any entities producing health care goods or services.

All presenters disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above.  No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Accreditation Statement:

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity. Other health care professionals are awarded (0.1) continuing education units (CEU) which are equivalent to 1 contact hour.

For your credit transcript, please access our website 4 weeks post-completion at and follow the link to the Credit Transcript page. If you do not provide the last 5 digits of your SSN on the next page you will not be able to access a CME credit transcript. Providing your SSN is voluntary.

Release Date: 5/2/2017 | Last Modified On: 5/2/2017 | Expires: 5/4/2020

This course has been expired.