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Corina Bondi, PhD, assistant professor of Physical Medicine and Rehabilitation at the University of Pittsburgh School of Medicine, was awarded a five-year, $1.4 million R01 grant entitled “Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function” from the National Institute of Neurological Disorders and Stroke.
Traumatic brain injuries (TBIs) affect 2.8 million people each year in the United States and cause long-lasting cognitive symptoms and mood changes. This project aims to characterize alterations in sustained attention, behavioral flexibility, and anxiety-like responses after TBIs in young, adult, and aged male and female rats.
Co-investigators of the grant include Anthony E. Kline, PhD, professor of physical medicine and rehabilitation, C. Edward Dixon, PhD, professor of neurological surgery, and Gina McKernan, PhD, research assistant professor and director of biostatistics core in physical medicine and rehabilitation.
Dr. Bondi’s research interests focus on characterizing therapeutic strategies after experimental TBI for complex cognitive processing difficulties and distinct neurobehavioral and neurochemical changes relevant to psychiatric disorders.
She is also a part of the Safar Center for Resuscitation Research — a part of the University of Pittsburgh School of Medicine — that aims to identify and promote methods to prevent premature death and disability from TBI, cardiac arrest, and other forms of acute brain injury.
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