UPMC Department of Orthopaedic Surgery Research Year in Review

November 21, 2020

The Department of Orthopaedic Surgery is committed to delivering the highest quality of diagnostic and therapeutic patient care for a diverse spectrum of orthopaedic disorders. Read about the research advances the Department has made over the last year.

Effects of Prosthesis Design and Placement on Shoulder Kinematics and Strength After Reverse Total Shoulder Arthroplasty

Albert Lin, MD, and William J. Anderst, PhD, were awarded an R03 grant from the NIH totaling more than $150,000 over the two-year project period. The research aims to determine the in vivo effect of prosthesis placement and design on shoulder kinematics and strength after reverse shoulder arthroplasty, and to identify the shoulder kinematics and strength parameters that are associated with improved clinical outcomes.

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STABILITY II: ACL Reconstruction +/- Lateral Tenodesis with Patellar vs. Quad Tendon

Volker Musahl, MD, and James J. Irrgang, PhD, PT, ATC, have been awarded a $3.2 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to conduct a prospective randomized international multicenter clinical trial to determine if the use of the quadriceps tendon versus patellar tendon, either with or without a lateral extra-articular tenodesis, reduces the risk of re-injury of the ACL, results in less symptoms and better function and quality of life and an improved ability to return to sports. The University of Pittsburgh is working in collaboration with Western Ontario University for this study. 

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STaR Trial: Multiple Ligament Knee Injuries

Volker Musahl, MD, and James J. Irrgang, PhD, PT, ATC, are serving as co-PIs for STaR (Surgical Timing and Rehabilitation for Multiligament Knee Injuries), a multicenter, randomized clinical trial. This $4.4 million grant from the Department of Defense will support two parallel, multicenter, randomized clinical trials to investigate the effects of timing of surgery (early versus delayed) and timing of postoperative rehabilitation (early versus delayed) for the treatment of multiple-ligament knee injuries.

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Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes Mechanistic Research Center (LB3P MRC) 

Gwendolyn Sowa, MD, PhD, chair of the Department of Physical Medicine and Rehabilitation, and Nam Vo, PhD, associate professor of orthopaedic surgery, were awarded more than $16 million to establish the LB3P MRC, a multidisciplinary research center dedicated to categorizing patients into subgroups of chronic low back pain with the goal of targeting treatments specific to individual patients’ pain and reducing the use of opioids.

Learn more here.